Common Synaptic Inputs to Human Upper Airway Muscles

Grant number: DP120101343 | Funding period: 2012 - 2015

Completed

Abstract

Changes in the activity of upper airway muscles at sleep onset contribute to the development of Obstructive Sleep Apnoea. The aim of this project is to investigate how the brain controls upper airway muscles during wakefulness and sleep and to identify the pathological processes that lead to the development of Obstructive Sleep Apnoea.

Related publications (5)

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Motor control of the palatoglossus and genioglossus during changes in breathing route

AS Jordan, MJ Woods, JM Cori, JKM Chan, CL Nicholas, J Semmler, J Trinder

2024-11-01

High activity of upper airway dilator muscles is thought to be critical in preventing sleep-related upper airway collapse. To date..

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Mechanisms of the deep, slow-wave, sleep-related increase of upper airway muscle tone in healthy humans

A Hicks, JM Cori, AS Jordan, CL Nicholas, L Kubin, JG Semmler, A Malhotra, DGP McSharry, JA Trinder

2017-05-01

Upper airway muscle activity is reportedly elevated during slow-wave sleep (SWS) when compared with lighter sleep stages. To uncov..

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Common drive to the upper airway muscle genioglossus during inspiratory loading

MJ Woods, CL Nicholas, JG Semmler, JKM Chan, AS Jordan, J Trinder

2015-11-17

Common drive is thought to constitute a central mechanism by which the efficiency of a motor neuron pool is increased. This study ..

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Crossed motor innervation of the base of human tongue

L Kubin, AS Jordan, CL Nicholas, JM Cori, JG Semmler, J Trinder

2015-06-01

Muscle fibers of the genioglossus (GG) form the bulk of the muscle mass at the base of the tongue. The motor control of the tongue..

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Motor unit activity in upper airway muscles genioglossus and tensor palatini

J Trinder, M Woods, CL Nicholas, JKM Chan, AS Jordan, JG Semmler

2013-09-15

Common oscillatory inputs to genioglossus (GG) and tensor palatini (TP) motoneurons were assessed using coherence analysis. Oscill..

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